Took a quick listen to it, what I took away is the books will take from Bram Stoker's Dracula in they want to have a bunch of letter correspondence between characters at the beginning of the book. During mentioning, Dilisnya in one of crypt of Strahd he mentions you can find out that oh one of the other Darklords of Borca is a Dilisnya. (So we know Borca is still a thing). Wes talks a few points that makes me happy that he seems to at the very least know or studied what he's talking about which is great. He talks about the fact that domains are hinted to be taken from other realms and copy pasted into the Domains of Dread or potentially taken wholesale.
There is a part where I don't recognize something when he's talking about "institutions" in Barovia. Or at least it seems like he's implying these organizations are in Barovia but I can't put place it. It's something like "Priest of Aus-su-bus" and "The Almost Inquisition" (sounds like Almost maybe it's something close sounding to that like Almus?) Anyways potentially it's around the 15:30 mark in the podcast.
There's also some interesting talk about how to change small things to get a different story out of the domain. This is paraphrased and possibly condensed but basically "What happens if Tatyana comes back as Twins? or a Ghost? Werewolf, or if she's a vampire hunter working along side you." He also later towards the end also mentions what if she's left Barovia and you need to go on a domain hopping adventure to get her or protect her from the minions of Strahd. (Tara Kolyana Confirmed, or at least hinted at for old lorists like us?)
Those are the tidbits I managed to extract from it while listening. Wes at the very least seems to know what he's talking about which is encouraging.