Yep, there are some large changes between the comic and the show, the biggest being that there are far less children present (Hershel had 2 little girls, the twins aren't present, etc). Tyreese is still to appear! Where is he?!
There have been a few changes since i was fed spoilers, but I had assumed some would be false, or may have been true at the time and later changed (like the end of episode 7 was very different to how I was first told), but it was still darn good, but it does effect things in a larger way down the line, but there's years of the show before that would have any major effect and then it's a subplot.
Hershel in episode 8 will be interesting even just to see how it reflects on the comic.
I just hate the fact we have to wait until February for more! Who's bright idea was it to put a break in a 13 episode season anyway? They should be brutally tortured!